They show a reduction in symptoms with probiotics

A study conducted by DuPont Nutrition & Health found that a probiotic formulation helps reduce symptoms caused by antibiotic use. A study investigating the ability of a unique probiotic formulation to reduce potential gastrointestinal adverse effects of antibiotic treatment found significant benefits in dietary supplementation with HOWARU® Restore, part of the DuPont™ Danisco® line of probiotics from DuPont Nutrition & Health.

The study, conducted by DuPont Nutrition & Health in collaboration with Changhai Hospital in Shanghai, was published in the journal Vaccine under the title: Clinical Dose Response Study Examines Use of Probiotics to Reduce Symptoms of Antibiotic Use probiotics to reduce the symptoms of taking antibiotics).

A triple-blind dose-response study concluded that a combination of four probiotic strains HOWARU® Restore appears to reduce the risk and duration of antibiotic-associated diarrhea (AAD). A reduction in gastrointestinal symptoms (fever, bloating and abdominal pain) was also observed compared to the placebo group.

503 adults who participated in the study were recruited from Changhai Hospital in Shanghai, China and were divided into three groups: a placebo group and two groups that received a low or high dose of HOWARU® Restore (minimum guaranteed dose: 2.5 × 109 and 10 × 109 colony forming units (CFU), at the end of shelf life). Both probiotics and placebo treatments were administered daily in capsule form for 7 days after antibiotic treatment.

While the low-dose group apparently had fewer adverse effects of antibiotics than the placebo group, the incidence of AAD in the high-dose group was 12.5 percent, almost half that of the placebo group (24.6 percent).

Likewise, the appearance of fever and discomfort gastrointestinal it was significantly lower in the high-dose group. In addition, the study indicates a trend toward a lower incidence of diarrhea caused by Clostridium difficile (DCD) – Clostridium difficile is the pathogenic microbe responsible for 10 to 25 percent of episodes of AAD and almost all episodes of antibiotic-induced pseudomembranous colitis.

“Few, if any, probiotics have been shown to reduce the duration and severity of AAD,” said Arthur Ouwehand, research director, DuPont Nutrition & Health. “This study confirms the positive dose-dependent effect of HOWARU® Restore when taken during and immediately after antibiotic treatment,” he added.

In addition to being one of the most important studies with probiotics and DAA, it is the only dose-response study of the effect of probiotics on DAA in adults to date.
“This is one of the few dose-response studies in probiotic research. In this case, the highest dose was found to be superior,” added Ouwehand.


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